Tissue-Specific Proteomics Analysis of Anti-COVID-19 Nucleoside and Nucleotide Prodrug-Activating Enzymes Provides Insights into the Optimization of Prodrug Design and Pharmacotherapy Strategy

[Image: see text] Nucleoside and nucleotide analogs are an essential class of antivirals for COVID-19 treatment. Several nucleoside/nucleotide analogs have shown promising effects against SARS-CoV-2 in vitro; however, their in vivo efficacy is limited. Nucleoside/nucleotide analogs are often formed...

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Detalles Bibliográficos
Autores principales: Li, Jiapeng, Liu, Shuhan, Shi, Jian, Wang, Xinwen, Xue, Yanling, Zhu, Hao-Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8033752/
https://www.ncbi.nlm.nih.gov/pubmed/33855276
http://dx.doi.org/10.1021/acsptsci.1c00016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8033752/
https://www.ncbi.nlm.nih.gov/pubmed/33855276
http://dx.doi.org/10.1021/acsptsci.1c00016

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