Integrated Multi-Omic Analyses of the Genomic Modifications by Gut Microbiome-Derived Metabolites of Epicatechin, 5-(4′-Hydroxyphenyl)-γ-Valerolactone, in TNFalpha-Stimulated Primary Human Brain Microvascular Endothelial Cells

Cerebral blood vessels are lined with endothelial cells and form the blood-brain barrier. Their dysfunction constitutes a crucial event in the physiopathology of neurodegenerative disorders and cognitive impairment. Epicatechin can improve cognitive functions and lower the risk for Alzheimer’s disea...

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Detalles Bibliográficos
Autores principales: Corral-Jara, Karla Fabiola, Nuthikattu, Saivageethi, Rutledge, John, Villablanca, Amparo, Morand, Christine, Schroeter, Hagen, Milenkovic, Dragan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8033932/
https://www.ncbi.nlm.nih.gov/pubmed/33841078
http://dx.doi.org/10.3389/fnins.2021.622640

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8033932/
https://www.ncbi.nlm.nih.gov/pubmed/33841078
http://dx.doi.org/10.3389/fnins.2021.622640

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