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Pharmacologic Treatment of Restless Legs Syndrome

Restless legs syndrome (RLS)/Willis-Ekbom disease is a neurologic disorder characterized by a strong desire to move when at rest (usually in the evening) and paraesthesia in their lower legs. The most widely used therapies for first-line treatment of RLS are dopaminergic drugs; however, their long-t...

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Autores principales: Lv, Qing, Wang, Xinlin, Asakawa, Tetsuya, Wang, Xiao Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8033969/
https://www.ncbi.nlm.nih.gov/pubmed/33380302
http://dx.doi.org/10.2174/1570159X19666201230150127
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author Lv, Qing
Wang, Xinlin
Asakawa, Tetsuya
Wang, Xiao Ping
author_facet Lv, Qing
Wang, Xinlin
Asakawa, Tetsuya
Wang, Xiao Ping
author_sort Lv, Qing
collection PubMed
description Restless legs syndrome (RLS)/Willis-Ekbom disease is a neurologic disorder characterized by a strong desire to move when at rest (usually in the evening) and paraesthesia in their lower legs. The most widely used therapies for first-line treatment of RLS are dopaminergic drugs; however, their long-term use can lead to augmentation. α2δ Ligands, opioids, iron, glutamatergic drugs, adenosine, and sleep aids have been investigated as alternatives. The pathogenesis of RLS is not well understood. Despite the efficacy of dopaminergic drugs in the treatment of this disorder, unlike in Parkinson’s disease dopaminergic cell loss in the substantia nigra has not been observed in RLS. The etiology of RLS is likely complex, involving multiple neural pathways. RLS-related genes identified in genome-wide association studies can provide insight into the mechanistic basis and pathophysiology of RLS. Here we review the current treatments and knowledge of the mechanisms underlying RLS.
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spelling pubmed-80339692021-09-01 Pharmacologic Treatment of Restless Legs Syndrome Lv, Qing Wang, Xinlin Asakawa, Tetsuya Wang, Xiao Ping Curr Neuropharmacol Article Restless legs syndrome (RLS)/Willis-Ekbom disease is a neurologic disorder characterized by a strong desire to move when at rest (usually in the evening) and paraesthesia in their lower legs. The most widely used therapies for first-line treatment of RLS are dopaminergic drugs; however, their long-term use can lead to augmentation. α2δ Ligands, opioids, iron, glutamatergic drugs, adenosine, and sleep aids have been investigated as alternatives. The pathogenesis of RLS is not well understood. Despite the efficacy of dopaminergic drugs in the treatment of this disorder, unlike in Parkinson’s disease dopaminergic cell loss in the substantia nigra has not been observed in RLS. The etiology of RLS is likely complex, involving multiple neural pathways. RLS-related genes identified in genome-wide association studies can provide insight into the mechanistic basis and pathophysiology of RLS. Here we review the current treatments and knowledge of the mechanisms underlying RLS. Bentham Science Publishers 2021-03 2021-03 /pmc/articles/PMC8033969/ /pubmed/33380302 http://dx.doi.org/10.2174/1570159X19666201230150127 Text en © 2021 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Lv, Qing
Wang, Xinlin
Asakawa, Tetsuya
Wang, Xiao Ping
Pharmacologic Treatment of Restless Legs Syndrome
title Pharmacologic Treatment of Restless Legs Syndrome
title_full Pharmacologic Treatment of Restless Legs Syndrome
title_fullStr Pharmacologic Treatment of Restless Legs Syndrome
title_full_unstemmed Pharmacologic Treatment of Restless Legs Syndrome
title_short Pharmacologic Treatment of Restless Legs Syndrome
title_sort pharmacologic treatment of restless legs syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8033969/
https://www.ncbi.nlm.nih.gov/pubmed/33380302
http://dx.doi.org/10.2174/1570159X19666201230150127
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