Engineering and crystal structure of a monomeric FLT3 ligand variant

The overarching paradigm for the activation of class III and V receptor tyrosine kinases (RTKs) prescribes cytokine-mediated dimerization of the receptor ectodomains and homotypic receptor–receptor interactions. However, structural studies have shown that the hematopoietic receptor FLT3, a class III...

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Detalles Bibliográficos
Autores principales: Pannecoucke, Erwin, Raes, Laurens, Savvides, Savvas N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2021
Materias:
Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8034431/
https://www.ncbi.nlm.nih.gov/pubmed/33830077
http://dx.doi.org/10.1107/S2053230X21003289

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8034431/
https://www.ncbi.nlm.nih.gov/pubmed/33830077
http://dx.doi.org/10.1107/S2053230X21003289

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