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Engineering and crystal structure of a monomeric FLT3 ligand variant

The overarching paradigm for the activation of class III and V receptor tyrosine kinases (RTKs) prescribes cytokine-mediated dimerization of the receptor ectodomains and homotypic receptor–receptor interactions. However, structural studies have shown that the hematopoietic receptor FLT3, a class III...

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Detalles Bibliográficos
Autores principales:	Pannecoucke, Erwin, Raes, Laurens, Savvides, Savvas N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Union of Crystallography 2021
Materias:	Research Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8034431/ https://www.ncbi.nlm.nih.gov/pubmed/33830077 http://dx.doi.org/10.1107/S2053230X21003289

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