Targeted-antibacterial-plasmids (TAPs) combining conjugation and CRISPR/Cas systems achieve strain-specific antibacterial activity

The global emergence of drug-resistant bacteria leads to the loss of efficacy of our antibiotics arsenal and severely limits the success of currently available treatments. Here, we developed an innovative strategy based on targeted-antibacterial-plasmids (TAPs) that use bacterial conjugation to deli...

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Detalles Bibliográficos
Autores principales: Reuter, Audrey, Hilpert, Cécile, Dedieu-Berne, Annick, Lematre, Sophie, Gueguen, Erwan, Launay, Guillaume, Bigot, Sarah, Lesterlin, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Synthetic Biology and Bioengineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8034655/
https://www.ncbi.nlm.nih.gov/pubmed/33660775
http://dx.doi.org/10.1093/nar/gkab126

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8034655/
https://www.ncbi.nlm.nih.gov/pubmed/33660775
http://dx.doi.org/10.1093/nar/gkab126

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