Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice

Prime editors (PEs) mediate genome modification without utilizing double-stranded DNA breaks or exogenous donor DNA as a template. PEs facilitate nucleotide substitutions or local insertions or deletions within the genome based on the template sequence encoded within the prime editing guide RNA (peg...

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Detalles Bibliográficos
Autores principales: Liu, Pengpeng, Liang, Shun-Qing, Zheng, Chunwei, Mintzer, Esther, Zhao, Yan G., Ponnienselvan, Karthikeyan, Mir, Aamir, Sontheimer, Erik J., Gao, Guangping, Flotte, Terence R., Wolfe, Scot A., Xue, Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8035190/
https://www.ncbi.nlm.nih.gov/pubmed/33837189
http://dx.doi.org/10.1038/s41467-021-22295-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8035190/
https://www.ncbi.nlm.nih.gov/pubmed/33837189
http://dx.doi.org/10.1038/s41467-021-22295-w

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