Cargando…

Deciphering the Binding Interactions between Acinetobacter baumannii ACP and β-ketoacyl ACP Synthase III to Improve Antibiotic Targeting Using NMR Spectroscopy

Fatty acid synthesis is essential for bacterial viability. Thus, fatty acid synthases (FASs) represent effective targets for antibiotics. Nevertheless, multidrug-resistant bacteria, including the human opportunistic bacteria, Acinetobacter baumannii, are emerging threats. Meanwhile, the FAS pathway...

Descripción completa

Detalles Bibliográficos
Autores principales:	Choi, Sungjae, Park, Jungwoo, Yeon, Jiwon, Jang, Ahjin, Lee, Woo Cheol, Kim, Yangmee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8036411/ https://www.ncbi.nlm.nih.gov/pubmed/33805050 http://dx.doi.org/10.3390/ijms22073317

Ejemplares similares

Structural comparison of Acinetobacter baumannii β-ketoacyl-acyl carrier protein reductases in fatty acid and aryl polyene biosynthesis
por: Lee, Woo Cheol, et al.
Publicado: (2021)

Gating mechanism of elongating β-ketoacyl-ACP synthases
por: Mindrebo, Jeffrey T., et al.
Publicado: (2020)

Platensimycin Activity against Mycobacterial β-Ketoacyl-ACP Synthases
por: Brown, Alistair K., et al.
Publicado: (2009)

Shewanella oneidensis FabB: A β-ketoacyl-ACP Synthase That Works with C16:1-ACP
por: Luo, Qixia, et al.
Publicado: (2016)

Structural Characterization of an ACP from Thermotoga maritima: Insights into Hyperthermal Adaptation
por: Lee, Yeongjoon, et al.
Publicado: (2020)

α-proteobacteria synthesize biotin precursor pimeloyl-ACP using BioZ 3-ketoacyl-ACP synthase and lysine catabolism
por: Hu, Yuanyuan, et al.
Publicado: (2020)

Review of Platensimycin and Platencin: Inhibitors of β-Ketoacyl-acyl Carrier Protein (ACP) Synthase III (FabH)
por: Shang, Ruofeng, et al.
Publicado: (2015)

Enhancing oil production in Arabidopsis through expression of a ketoacyl-ACP synthase domain of the PUFA synthase from Thraustochytrium
por: Xie, Xi, et al.
Publicado: (2019)

Structural Insight of KSIII (β-Ketoacyl-ACP Synthase)-like Acyltransferase ChlB3 in the Biosynthesis of Chlorothricin
por: Saeed, Asad Ullah, et al.
Publicado: (2022)

Insights into Acinetobacter baumannii fatty acid synthesis 3-oxoacyl-ACP reductases
por: Cross, Emily M., et al.
Publicado: (2021)

Improved chemical and isotopic labeling of biomembranes in Bacillus subtilis by leveraging CRISPRi inhibition of beta-ketoacyl-ACP synthase (fabF)
por: Nickels, Jonathan D., et al.
Publicado: (2022)

A cryptic long-chain 3-ketoacyl-ACP synthase in the Pseudomonas putida F1 unsaturated fatty acid synthesis pathway
por: Dong, Huijuan, et al.
Publicado: (2021)

Role of Serine140 in the mode of action of Mycobacterium tuberculosis β-ketoacyl-ACP Reductase (MabA)
por: Rosado, Leonardo A, et al.
Publicado: (2012)

Structure-based identification of novel inhibitors targeting the enoyl-ACP reductase enzyme of Acinetobacter baumannii
por: Khan, Shama, et al.
Publicado: (2023)

Modulation of Medium-Chain Fatty Acid Synthesis in Synechococcus sp. PCC 7002 by Replacing FabH with a Chaetoceros Ketoacyl-ACP Synthase
por: Gu, Huiya, et al.
Publicado: (2016)

Three-dimensional (3D) structure prediction of the American and African oil-palms β-ketoacyl-[ACP] synthase-II protein by comparative modelling
por: Wang, Edina, et al.
Publicado: (2014)

Insights from computational analysis of full-length β-ketoacyl-[ACP] synthase-II cDNA isolated from American and African oil palms
por: Bhore, Subhash J., et al.
Publicado: (2014)

Mechanism and Substrate Recognition of Human Holo ACP Synthase
por: Bunkoczi, Gabor, et al.
Publicado: (2007)

ACP basic statistics = ACP, statistiques de base.
Publicado: (1985)

Cloning of the pks3 gene of Aurantiochytrium limacinum and functional study of the 3-ketoacyl-ACP reductase and dehydratase enzyme domains
por: Liu, Zhu, et al.
Publicado: (2018)

Modeling holo-ACP:DH and holo-ACP:KR complexes of modular polyketide synthases: a docking and molecular dynamics study
por: Anand, Swadha, et al.
Publicado: (2012)

GCNCPR-ACPs: a novel graph convolution network method for ACPs prediction
por: Wu, Xiujin, et al.
Publicado: (2022)

Escherichia coli FabG 3-ketoacyl-ACP reductase proteins lacking the assigned catalytic triad residues are active enzymes
por: Hu, Zhe, et al.
Publicado: (2021)

Development of Novel Peptides for the Antimicrobial Combination Therapy against Carbapenem-Resistant Acinetobacter baumannii Infection
por: Choi, Joonhyeok, et al.
Publicado: (2021)

Identification of 2-Aminothiazole-4-Carboxylate Derivatives Active against Mycobacterium tuberculosis H(37)R(v) and the β-Ketoacyl-ACP Synthase mtFabH
por: Al-Balas, Qosay, et al.
Publicado: (2009)

Antiseptic 9-Meric Peptide with Potency against Carbapenem-Resistant Acinetobacter baumannii Infection
por: Krishnan, Manigandan, et al.
Publicado: (2021)

DLFF-ACP: prediction of ACPs based on deep learning and multi-view features fusion
por: Cao, Ruifen, et al.
Publicado: (2021)

Structural basis of the complementary activity of two ketosynthases in aryl polyene biosynthesis
por: Lee, Woo Cheol, et al.
Publicado: (2021)

ACP medicine : a publication of the American College of Physicians /
Publicado: (2004)

Genetic enhancement of palmitic acid accumulation in cotton seed oil through RNAi down‐regulation of ghKAS2 encoding β‐ketoacyl‐ACP synthase II (KASII)
por: Liu, Qing, et al.
Publicado: (2016)

Interrogation of Essentiality in the Reconstructed Haemophilus influenzae Metabolic Network Identifies Lipid Metabolism Antimicrobial Targets: Preclinical Evaluation of a FabH β-Ketoacyl-ACP Synthase Inhibitor
por: López-López, Nahikari, et al.
Publicado: (2022)

Targeting of the Essential acpP, ftsZ, and rne Genes in Carbapenem-Resistant Acinetobacter baumannii by Antisense PNA Precision Antibacterials
por: Nejad, Alireza Japoni, et al.
Publicado: (2021)

The Interactions of CPP–ACP with Saliva
por: Huq, Noorjahan Laila, et al.
Publicado: (2016)

ACP Conference on Fundamental Physics of Ferroelectrics
por: Cohen, Ronald E
Publicado: (2000)

Maryland ACP Winning Abstracts 2017
Publicado: (2017)

Intraarticular ACP therapy for severe osteoarthritis
por: Borsky, Michael
Publicado: (2019)

Ligand-protein interactions of plant-isolated (9z,12z)-octadeca-9,12-dienoic acid with Β-ketoacyl-Acp synthase (KasA) in potential anti-tubercular drug designing
por: Mtewa, Andrew G., et al.
Publicado: (2021)

Enamel defects in Acp4(R110C/R110C) mice and human ACP4 mutations
por: Liang, Tian, et al.
Publicado: (2022)

Institutional and Cultural Barriers to ACP: Staff Perspectives
por: Gutman, Gloria, et al.
Publicado: (2020)

What Matters Most: ACP Evolving in Practice
por: Valadares, Kevin
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_nuf27oorbnu57s5kpuhmdu5rfc