Heterogeneities in Cell Cycle Checkpoint Activation Following Doxorubicin Treatment Reveal Targetable Vulnerabilities in TP53 Mutated Ultra High-Risk Neuroblastoma Cell Lines

Most chemotherapeutics target DNA integrity and thereby trigger tumour cell death through activation of DNA damage responses that are tightly coupled to the cell cycle. Disturbances in cell cycle regulation can therefore lead to treatment resistance. Here, a comprehensive analysis of cell cycle chec...

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Detalles Bibliográficos
Autores principales: Ödborn Jönsson, Linnéa, Sahi, Maryam, Lopez-Lorenzo, Ximena, Keller, Faye Leilah, Kostopoulou, Ourania N., Herold, Nikolas, Ährlund-Richter, Lars, Shirazi Fard, Shahrzad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8036447/
https://www.ncbi.nlm.nih.gov/pubmed/33915913
http://dx.doi.org/10.3390/ijms22073664

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8036447/
https://www.ncbi.nlm.nih.gov/pubmed/33915913
http://dx.doi.org/10.3390/ijms22073664

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