Synthesis, Biological Activity, and Molecular Dynamics Study of Novel Series of a Trimethoprim Analogs as Multi-Targeted Compounds: Dihydrofolate Reductase (DHFR) Inhibitors and DNA-Binding Agents

Eighteen previously undescribed trimethoprim (TMP) analogs containing amide bonds (1–18) were synthesized and compared with TMP, methotrexate (MTX), and netropsin (NT). These compounds were designed as potential minor groove binding agents (MGBAs) and inhibitors of human dihydrofolate reductase (hDH...

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Detalles Bibliográficos
Autores principales: Wróbel, Agnieszka, Baradyn, Maciej, Ratkiewicz, Artur, Drozdowska, Danuta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037161/
https://www.ncbi.nlm.nih.gov/pubmed/33916202
http://dx.doi.org/10.3390/ijms22073685

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037161/
https://www.ncbi.nlm.nih.gov/pubmed/33916202
http://dx.doi.org/10.3390/ijms22073685

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