Covalent Cysteine Targeting of Bruton’s Tyrosine Kinase (BTK) Family by Withaferin-A Reduces Survival of Glucocorticoid-Resistant Multiple Myeloma MM1 Cells

SIMPLE SUMMARY: Glucocorticoid therapy resistance in B-cell malignancies is often associated with constitutive activation of tyrosine kinases. Novel anticancer drugs targeting hyperactivated tyrosine kinases, such as Bruton’s tyrosine kinase (BTK), have, therefore, gained much interest over the past...

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Detalles Bibliográficos
Autores principales: Logie, Emilie, Chirumamilla, Chandra S., Perez-Novo, Claudina, Shaw, Priyanka, Declerck, Ken, Palagani, Ajay, Rangarajan, Savithri, Cuypers, Bart, De Neuter, Nicolas, Mobashar Hussain Urf Turabe, Fazil, Kumar Verma, Navin, Bogaerts, Annemie, Laukens, Kris, Offner, Fritz, Van Vlierberghe, Pieter, Van Ostade, Xaveer, Berghe, Wim Vanden
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037275/
https://www.ncbi.nlm.nih.gov/pubmed/33807411
http://dx.doi.org/10.3390/cancers13071618

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037275/
https://www.ncbi.nlm.nih.gov/pubmed/33807411
http://dx.doi.org/10.3390/cancers13071618

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