Metabolite Profiling and Characterization of LW6, a Novel HIF-1α Inhibitor, as an Antitumor Drug Candidate in Mice

A novel HIF (hypoxia-inducible factor)-1α inhibitor, the (aryloxyacetylamino)benzoic acid derivative LW6, is an anticancer agent that inhibits the accumulation of HIF-1α. The aim of this study was to characterize and determine the structures of the metabolites of LW6 in ICR mice. Metabolite identifi...

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Detalles Bibliográficos
Autores principales: Lee, Kiho, Lee, Ji-Yoon, Lee, Kyeong, Jung, Cho-Rock, Kim, Min-Ju, Kim, Jung-Ah, Yoo, Dong-Gu, Shin, Eun-Jin, Oh, Soo-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037336/
https://www.ncbi.nlm.nih.gov/pubmed/33808438
http://dx.doi.org/10.3390/molecules26071951

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037336/
https://www.ncbi.nlm.nih.gov/pubmed/33808438
http://dx.doi.org/10.3390/molecules26071951

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