Cargando…

Metabolite Profiling and Characterization of LW6, a Novel HIF-1α Inhibitor, as an Antitumor Drug Candidate in Mice

A novel HIF (hypoxia-inducible factor)-1α inhibitor, the (aryloxyacetylamino)benzoic acid derivative LW6, is an anticancer agent that inhibits the accumulation of HIF-1α. The aim of this study was to characterize and determine the structures of the metabolites of LW6 in ICR mice. Metabolite identifi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Kiho, Lee, Ji-Yoon, Lee, Kyeong, Jung, Cho-Rock, Kim, Min-Ju, Kim, Jung-Ah, Yoo, Dong-Gu, Shin, Eun-Jin, Oh, Soo-Jin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037336/ https://www.ncbi.nlm.nih.gov/pubmed/33808438 http://dx.doi.org/10.3390/molecules26071951

Ejemplares similares

Pharmacokinetic Characterization of LW6, a Novel Hypoxia-Inducible Factor-1α (HIF-1α) Inhibitor in Mice
por: Lee, Ji-Yoon, et al.
Publicado: (2021)

The disubstituted adamantyl derivative LW1564 inhibits the growth of cancer cells by targeting mitochondrial respiration and reducing hypoxia-inducible factor (HIF)-1α accumulation
por: Kim, Inhyub, et al.
Publicado: (2020)

NQO1 inhibits proteasome-mediated degradation of HIF-1α
por: Oh, Eun-Taex, et al.
Publicado: (2016)

Impairment of HIF-1α-mediated metabolic adaption by NRF2-silencing in breast cancer cells
por: Lee, Sujin, et al.
Publicado: (2019)

LW1497, an Inhibitor of Malate Dehydrogenase, Suppresses TGF-β1-Induced Epithelial-Mesenchymal Transition in Lung Cancer Cells by Downregulating Slug
por: Kim, Hyun Ji, et al.
Publicado: (2021)

Effects of long-term tubular HIF-2α overexpression on progressive renal fibrosis in a chronic kidney disease model
por: Kim, Dal-Ah, et al.
Publicado: (2023)

Heme oxygenase metabolites improve astrocytic mitochondrial function via a Ca(2+)-dependent HIF-1α/ERRα circuit
por: Choi, Yoon Kyung, et al.
Publicado: (2018)

Development of a Ternary Solid Dispersion Formulation of LW6 to Improve the In Vivo Activity as a BCRP Inhibitor: Preparation and In Vitro/In Vivo Characterization
por: Bajracharya, Rajiv, et al.
Publicado: (2019)

Minoxidil Induction of VEGF Is Mediated by Inhibition of HIF-Prolyl Hydroxylase
por: Yum, Soohwan, et al.
Publicado: (2017)

HDAC8 Deacetylates HIF-1α and Enhances Its Protein Stability to Promote Tumor Growth and Migration in Melanoma
por: Kim, Ji Yoon, et al.
Publicado: (2023)

KAI1 suppresses HIF-1α and VEGF expression by blocking CDCP1-enhanced Src activation in prostate cancer
por: Park, Jung-Jin, et al.
Publicado: (2012)

Transglutaminase 2-Mediated p53 Depletion Promotes Angiogenesis by Increasing HIF-1α-p300 Binding in Renal Cell Carcinoma
por: Lee, Seon-Hyeong, et al.
Publicado: (2020)

Dynamic Oxygen Conditions Promote the Translocation of HIF-1α to the Nucleus in Mouse Blastocysts
por: Choi, Jungwon, et al.
Publicado: (2021)

Adenovirus expressing dual c-Met-specific shRNA exhibits potent antitumor effect through autophagic cell death accompanied by senescence-like phenotypes in glioblastoma cells
por: Lee, Jung-Sun, et al.
Publicado: (2015)

Therapeutic Effects of HIF-1α on Bone Formation around Implants in Diabetic Mice Using Cell-Penetrating DNA-Binding Protein
por: Oh, Sang-Min, et al.
Publicado: (2019)

Hif-1α Inhibitors Could Successfully Inhibit the Progression of Differentiated Thyroid Cancer in Vitro
por: Kim, Min-Hee, et al.
Publicado: (2020)

MicroRNA-382 induced by HIF-1α is an angiogenic miR targeting the tumor suppressor phosphatase and tensin homolog
por: Seok, Jin-Kyung, et al.
Publicado: (2014)

Determination of HIF-1α degradation pathways via modulation of the propionyl mark
por: Jeong, Kwanyoung, et al.
Publicado: (2023)

Do not confuse anti-LW autoantibodies with anti-D
por: Miola, Marcos Paulo, et al.
Publicado: (2013)

Role of HIF1α Regulatory Factors in Stem Cells
por: Lee, Hyun Jik, et al.
Publicado: (2019)

Suppression of Akt-HIF-1α signaling axis by diacetyl atractylodiol inhibits hypoxia-induced angiogenesis
por: Choi, Sik-Won, et al.
Publicado: (2016)

Docetaxel induced-JNK2/PHD1 signaling pathway increases degradation of HIF-1α and causes cancer cell death under hypoxia
por: Oh, Eun-Taex, et al.
Publicado: (2016)

Clinicopathologic significance of HIF-1α, p53, and VEGF expression and preoperative serum VEGF level in gastric cancer
por: Oh, Sung Yong, et al.
Publicado: (2008)

MicroRNA-365 regulates IL-1β-induced catabolic factor expression by targeting HIF-2α in primary chondrocytes
por: Hwang, Hyun Sook, et al.
Publicado: (2017)

NADH elevation during chronic hypoxia leads to VHL-mediated HIF-1α degradation via SIRT1 inhibition
por: Joo, Hyun-Yoo, et al.
Publicado: (2023)

BICD1 mediates HIF1α nuclear translocation in mesenchymal stem cells during hypoxia adaptation
por: Lee, Hyun Jik, et al.
Publicado: (2018)

Genotype-phenotype analysis of von Hippel-Lindau syndrome in Korean families: HIF-α binding site missense mutations elevate age-specific risk for CNS hemangioblastoma
por: Lee, Jee-Soo, et al.
Publicado: (2016)

Adipocyte HIF2α functions as a thermostat via PKA Cα regulation in beige adipocytes
por: Han, Ji Seul, et al.
Publicado: (2022)

Thymoquinone Selectively Kills Hypoxic Renal Cancer Cells by Suppressing HIF-1α-Mediated Glycolysis
por: Lee, Yoon-Mi, et al.
Publicado: (2019)

Fascaplysin Exerts Anti-Cancer Effects through the Downregulation of Survivin and HIF-1α and Inhibition of VEGFR2 and TRKA
por: Oh, Taek-In, et al.
Publicado: (2017)

MicroRNA-18a regulates the metastatic properties of oral squamous cell carcinoma cells via HIF-1α expression
por: Kim, Shihyun, et al.
Publicado: (2022)

Inhibition of HIF-1α by Atorvastatin During (131)I-RTX Therapy in Burkitt’s Lymphoma Model
por: Kim, Eun-Ho, et al.
Publicado: (2020)

The Histone Methyltransferase Inhibitor BIX01294 Inhibits HIF-1α Stability and Angiogenesis
por: Oh, Su Young, et al.
Publicado: (2015)

Clinical significance of HIF-2α immunostaining area in radioresistant cervical cancer
por: Kim, Min Kyu, et al.
Publicado: (2011)

Extracellular Citrate Treatment Induces HIF1α Degradation and Inhibits the Growth of Low-Glycolytic Hepatocellular Carcinoma under Hypoxia
por: Kim, Seon Yoo, et al.
Publicado: (2022)

Pauli Manuscript Collection: Berechnung der Koeffizienten Le und Lw
por: [unknown]
Publicado: (2002)

Antitumor and apoptosis-inducing effects of α-mangostin extracted from the pericarp of the mangosteen fruit (Garcinia mangostana L.) in YD-15 tongue mucoepidermoid carcinoma cells
por: LEE, HAE NIM, et al.
Publicado: (2016)

Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis
por: Kim, Yunho, et al.
Publicado: (2016)

Association of TLR 9 gene polymorphisms with remission in patients with rheumatoid arthritis receiving TNF-α inhibitors and development of machine learning models
por: Kim, Woorim, et al.
Publicado: (2021)

The combination of sorafenib and radiation preferentially inhibits breast cancer stem cells by suppressing HIF-1α expression
por: LEE, JAE HO, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_ksgrumrccvmd11kev6sn4utv5c