Cargando…

Type III TGF-β Receptor Down-Regulation Promoted Tumor Progression via Complement Component C5a Induction in Hepatocellular Carcinoma

SIMPLE SUMMARY: The clinical implications of TGFβR3 downregulation are currently unknown in hepatocellular carcinoma (HCC). Clinically, we identified that HCC patients with low expression levels of tumoral TGFβR3 exhibited significantly late tumor stages and shortened survival outcomes. Moreover, HC...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yeung, Oscar Wai Ho, Qi, Xiang, Pang, Li, Liu, Hui, Ng, Kevin Tak Pan, Liu, Jiang, Lo, Chung Mau, Man, Kwan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037431/ https://www.ncbi.nlm.nih.gov/pubmed/33805946 http://dx.doi.org/10.3390/cancers13071503

Ejemplares similares

Early-phase circulating miRNAs predict tumor recurrence and survival of hepatocellular carcinoma patients after liver transplantation
por: NG, Kevin Tak-Pan, et al.
Publicado: (2016)

Glutathione S-transferase A2 promotes hepatocellular carcinoma recurrence after liver transplantation through modulating reactive oxygen species metabolism
por: Ng, Kevin Tak-Pan, et al.
Publicado: (2021)

Clinical significance and functional role of transmembrane protein 47 (TMEM47) in chemoresistance of hepatocellular carcinoma
por: Ng, Kevin Tak-Pan, et al.
Publicado: (2020)

An update on the role of complement in hepatocellular carcinoma
por: Xiao, Zhijie, et al.
Publicado: (2022)

Monocytic MDSC mobilization promotes tumor recurrence after liver transplantation via CXCL10/TLR4/MMP14 signaling
por: Liu, Hui, et al.
Publicado: (2021)

Clinical significance and therapeutic value of glutathione peroxidase 3 (GPx3) in hepatocellular carcinoma
por: Qi, Xiang, et al.
Publicado: (2014)

Development of cisplatin-loaded hydrogels for trans-portal vein chemoembolization in an orthotopic liver cancer mouse model
por: Yang, Xinxiang, et al.
Publicado: (2021)

Arachidonic acid activates NLRP3 inflammasome in MDSCs via FATP2 to promote post-transplant tumour recurrence in steatotic liver grafts
por: Liu, Hui, et al.
Publicado: (2023)

Proline-Rich Tyrosine Kinase 2 (Pyk2) Promotes Cell Motility of Hepatocellular Carcinoma through Induction of Epithelial to Mesenchymal Transition
por: Sun, Chris K., et al.
Publicado: (2011)

The Landscape of Aberrant Alternative Splicing Events in Steatotic Liver Graft Post Transplantation via Transcriptome-Wide Analysis
por: Liu, Hui, et al.
Publicado: (2023)

A hemoglobin-based oxygen carrier sensitized Cisplatin based chemotherapy in hepatocellular carcinoma
por: Qi, Xiang, et al.
Publicado: (2017)

Repressor and activator protein accelerates hepatic ischemia reperfusion injury by promoting neutrophil inflammatory response
por: Li, Chang Xian, et al.
Publicado: (2016)

Clinical relevance and therapeutic potential of angiopoietin-like protein 4 in hepatocellular carcinoma
por: Ng, Kevin Tak-Pan, et al.
Publicado: (2014)

THE INACTIVATION OF COMPLEMENT AND ITS COMPONENTS BY PLASMIN
por: Pillemer, Louis, et al.
Publicado: (1953)

Fusion with stem cell makes the hepatocellular carcinoma cells similar to liver tumor-initiating cells
por: Wang, Ran, et al.
Publicado: (2016)

The Clinical Significance and Potential Therapeutic Role of GPx3 in Tumor Recurrence after Liver Transplantation
por: Qi, Xiang, et al.
Publicado: (2016)

Prognostic Value of Complement Component 2 and Its Correlation with Immune Infiltrates in Hepatocellular Carcinoma
por: Ning, Gang, et al.
Publicado: (2020)

Down-Regulation of TGF-β Expression Sensitizes the Resistance of Hepatocellular Carcinoma Cells to Sorafenib
por: Kang, Dongxu, et al.
Publicado: (2017)

Glutathione Peroxidase 3 Delivered by hiPSC-MSCs Ameliorated Hepatic IR Injury via Inhibition of Hepatic Senescence
por: Qi, Xiang, et al.
Publicado: (2018)

Activated Complement Component 3 (C3) Is Required for Ultraviolet Induction of Immunosuppression and Antigenic Tolerance
por: Hammerberg, Craig, et al.
Publicado: (1998)

Tumour extracellular vesicle‐derived Complement Factor H promotes tumorigenesis and metastasis by inhibiting complement‐dependent cytotoxicity of tumour cells
por: Mao, Xiaowen, et al.
Publicado: (2020)

PDGF-D Expression Is Down-Regulated by TGFβ in Fibroblasts
por: Charni Chaabane, Saima, et al.
Publicado: (2014)

DEFICIENCY OF THE FIFTH COMPONENT OF COMPLEMENT IN MICE WITH AN INHERITED COMPLEMENT DEFECT
por: Nilsson, Ulf R., et al.
Publicado: (1967)

DEFICIENCY OF THE SIXTH COMPONENT OF COMPLEMENT IN RABBITS WITH AN INHERITED COMPLEMENT DEFECT
por: Rother, Klaus, et al.
Publicado: (1966)

Transcriptome Analysis of Acute Phase Liver Graft Injury in Liver Transplantation
por: Lee, Nikki P., et al.
Publicado: (2018)

SOME PROPERTIES OF AN ESTERASE DERIVED FROM PREPARATIONS OF THE FIRST COMPONENT OF COMPLEMENT
por: Ratnoff, Oscar D., et al.
Publicado: (1957)

The Role of Proline Rich Tyrosine Kinase 2 (Pyk2) on Cisplatin Resistance in Hepatocellular Carcinoma
por: Geng, Wei, et al.
Publicado: (2011)

Identification of the Sixth Complement Component as Potential Key Genes in Hepatocellular Carcinoma via Bioinformatics Analysis
por: Mu, Di, et al.
Publicado: (2020)

THE INFLUENCE OF CALCIUM IONS ON THE INACTIVATION OF HUMAN COMPLEMENT AND ITS COMPONENTS BY PLASMIN
por: Lepow, Irwin H., et al.
Publicado: (1953)

Comprehensive analysis of complement-associated molecular features in hepatocellular carcinoma: Complement-associated molecular features in hepatocellular carcinoma
por: Huang, Run, et al.
Publicado: (2022)

The role of complement in the clinical course of hepatocellular carcinoma
por: Qian, Xinye, et al.
Publicado: (2021)

STUDIES ON COMPLEMENT FIXATION IN TUBERCULOSIS. III
por: Lewis, Paul A.
Publicado: (1927)

FUNCTION OF COMPONENTS OF COMPLEMENT IN IMMUNE HEMOLYSIS
por: Pillemer, L., et al.
Publicado: (1942)

The Expression Profile of Complement Components in Podocytes
por: Li, Xuejuan, et al.
Publicado: (2016)

The Value of Targeting Complement Components in Asthma
por: Mohamed, Marwa M. E., et al.
Publicado: (2020)

Gene Variations of Sixth Complement Component Affecting Tacrolimus Metabolism in Patients with Liver Transplantation for Hepatocellular Carcinoma
por: Liao, Jian-Hua, et al.
Publicado: (2017)

FTY720 Suppresses Liver Tumor Growth and Metastasis by Reducing Circulating Regulating T Cells and Enhancing the Anti-Tumor Effect of Rapamycin
por: Li, Chang Xian, et al.
Publicado: (2020)

A Garlic Derivative, S-allylcysteine (SAC), Suppresses Proliferation and Metastasis of Hepatocellular Carcinoma
por: Ng, Kevin T. P., et al.
Publicado: (2012)

Increased type III TGF-β receptor shedding decreases tumorigenesis through induction of epithelial-to-mesenchymal transition
por: Huang, Jennifer J., et al.
Publicado: (2019)

miR-874-3p is down-regulated in hepatocellular carcinoma and negatively regulates PIN1 expression
por: Leong, Ka-Wai, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_9m4rci1l438eurqb12kj7965k6