Osmolality Effects on CHO Cell Growth, Cell Volume, Antibody Productivity and Glycosylation

The addition of nutrients and accumulation of metabolites in a fed-batch culture of Chinese hamster ovary (CHO) cells leads to an increase in extracellular osmolality in late stage culture. Herein, we explore the effect of osmolality on CHO cell growth, specific monoclonal antibody (mAb) productivit...

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Detalles Bibliográficos
Autores principales: Alhuthali, Sakhr, Kotidis, Pavlos, Kontoravdi, Cleo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037477/
https://www.ncbi.nlm.nih.gov/pubmed/33804825
http://dx.doi.org/10.3390/ijms22073290

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037477/
https://www.ncbi.nlm.nih.gov/pubmed/33804825
http://dx.doi.org/10.3390/ijms22073290

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