Synthesis and Hybrid SAR Property Modeling of Novel Cholinesterase Inhibitors †

A library of novel 4-{[(benzyloxy)carbonyl]amino}-2-hydroxybenzoic acid amides was designed and synthesized in order to provide potential acetyl- and butyrylcholinesterase (AChE/BChE) inhibitors; the in vitro inhibitory profile and selectivity index were specified. Benzyl(3-hydroxy-4-{[2-(trifluorom...

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Detalles Bibliográficos
Autores principales: Kos, Jiri, Kozik, Violetta, Pindjakova, Dominika, Jankech, Timotej, Smolinski, Adam, Stepankova, Sarka, Hosek, Jan, Oravec, Michal, Jampilek, Josef, Bak, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037530/
https://www.ncbi.nlm.nih.gov/pubmed/33810550
http://dx.doi.org/10.3390/ijms22073444

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037530/
https://www.ncbi.nlm.nih.gov/pubmed/33810550
http://dx.doi.org/10.3390/ijms22073444

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