Computational Analysis of the Interactions between the S100B Extracellular Chaperone and Its Amyloid β Peptide Client

S100B is an astrocytic extracellular Ca(2+)-binding protein implicated in Alzheimer’s disease, whose role as a holdase-type chaperone delaying Aβ(42) aggregation and toxicity was recently uncovered. Here, we employ computational biology approaches to dissect the structural details and dynamics of th...

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Detalles Bibliográficos
Autores principales: Rodrigues, Filipe E. P., Figueira, António J., Gomes, Cláudio M., Machuqueiro, Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037576/
https://www.ncbi.nlm.nih.gov/pubmed/33807304
http://dx.doi.org/10.3390/ijms22073629

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037576/
https://www.ncbi.nlm.nih.gov/pubmed/33807304
http://dx.doi.org/10.3390/ijms22073629

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