Synthesis and Enantioselective Pharmacokinetic/Pharmacodynamic Analysis of New CNS-Active Sulfamoylphenyl Carbamate Derivatives

We recently reported a new class of carbamate derivatives as anticonvulsants. Among these, 3-methylpentyl(4-sulfamoylphenyl)carbamate (MSPC) stood out as the most potent compound with ED(50) values of 13 mg/kg (i.p.) and 28 mg/kg (p.o.) in the rat maximal electroshock test (MES). 3-Methylpropyl(4-su...

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Detalles Bibliográficos
Autores principales: Odi, Reem, Bibi, David, Shusterman, Bella, Erenburg, Natalia, Shaul, Chanan, Supuran, Claudiu T., Nocentini, Alessio, Bialer, Meir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037586/
https://www.ncbi.nlm.nih.gov/pubmed/33806023
http://dx.doi.org/10.3390/ijms22073361

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037586/
https://www.ncbi.nlm.nih.gov/pubmed/33806023
http://dx.doi.org/10.3390/ijms22073361

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