Mechanisms of Resistance to PI3K Inhibitors in Cancer: Adaptive Responses, Drug Tolerance and Cellular Plasticity

SIMPLE SUMMARY: The phosphoinositide-3-kinase (PI3K) pathway is the most frequently activated pathway in human cancers. Consequently, a number of compounds targeting the various nodes of this pathway have been developed. However, the majority of these compounds have been unsuccessful in patients due...

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Detalles Bibliográficos
Autores principales: Wright, Sarah Christine Elisabeth, Vasilevski, Natali, Serra, Violeta, Rodon, Jordi, Eichhorn, Pieter Johan Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037590/
https://www.ncbi.nlm.nih.gov/pubmed/33810522
http://dx.doi.org/10.3390/cancers13071538

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037590/
https://www.ncbi.nlm.nih.gov/pubmed/33810522
http://dx.doi.org/10.3390/cancers13071538

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