Downfalls of Chemical Probes Acting at the Kinase ATP-Site: CK2 as a Case Study

Protein kinases are a large class of enzymes with numerous biological roles and many have been implicated in a vast array of diseases, including cancer and the novel coronavirus infection COVID-19. Thus, the development of chemical probes to selectively target each kinase is of great interest. Inhib...

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Detalles Bibliográficos
Autores principales: Atkinson, Eleanor L., Iegre, Jessica, Brear, Paul D., Zhabina, Elizabeth A., Hyvönen, Marko, Spring, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037657/
https://www.ncbi.nlm.nih.gov/pubmed/33807474
http://dx.doi.org/10.3390/molecules26071977

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037657/
https://www.ncbi.nlm.nih.gov/pubmed/33807474
http://dx.doi.org/10.3390/molecules26071977

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