Discovery of Novel Sultone Fused Berberine Derivatives as Promising Tdp1 Inhibitors

A new type of berberine derivatives was obtained by the reaction of berberrubine with aliphatic sulfonyl chlorides. The new polycyclic compounds have a sultone ring condensed to C and D rings of a protoberberine core. The reaction conditions were developed to facilitate the formation of sultones wit...

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Detalles Bibliográficos
Autores principales: Gladkova, Elizaveta D., Chepanova, Arina A., Ilina, Ekaterina S., Zakharenko, Alexandra L., Reynisson, Jóhannes, Luzina, Olga A., Volcho, Konstantin P., Lavrik, Olga I., Salakhutdinov, Nariman F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037669/
https://www.ncbi.nlm.nih.gov/pubmed/33808389
http://dx.doi.org/10.3390/molecules26071945

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037669/
https://www.ncbi.nlm.nih.gov/pubmed/33808389
http://dx.doi.org/10.3390/molecules26071945

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