CRISPR/Cas9 Deletion of SOX2 Regulatory Region 2 (SRR2) Decreases SOX2 Malignant Activity in Glioblastoma

SIMPLE SUMMARY: Understanding how SOX2, a major driver of cancer stem cells, is regulated in cancer cells is relevant to tackle tumorigenesis. In this study, we deleted the SRR2 regulatory region in glioblastoma cells. Our data confirm that the SRR2 enhancer regulates SOX2 expression in cancer and r...

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Detalles Bibliográficos
Autores principales: Saenz-Antoñanzas, Ander, Moncho-Amor, Veronica, Auzmendi-Iriarte, Jaione, Elua-Pinin, Alejandro, Rizzoti, Karine, Lovell-Badge, Robin, Matheu, Ander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037847/
https://www.ncbi.nlm.nih.gov/pubmed/33805518
http://dx.doi.org/10.3390/cancers13071574

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037847/
https://www.ncbi.nlm.nih.gov/pubmed/33805518
http://dx.doi.org/10.3390/cancers13071574

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