Cargando…

CRISPR/Cas9 Deletion of SOX2 Regulatory Region 2 (SRR2) Decreases SOX2 Malignant Activity in Glioblastoma

SIMPLE SUMMARY: Understanding how SOX2, a major driver of cancer stem cells, is regulated in cancer cells is relevant to tackle tumorigenesis. In this study, we deleted the SRR2 regulatory region in glioblastoma cells. Our data confirm that the SRR2 enhancer regulates SOX2 expression in cancer and r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Saenz-Antoñanzas, Ander, Moncho-Amor, Veronica, Auzmendi-Iriarte, Jaione, Elua-Pinin, Alejandro, Rizzoti, Karine, Lovell-Badge, Robin, Matheu, Ander
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037847/ https://www.ncbi.nlm.nih.gov/pubmed/33805518 http://dx.doi.org/10.3390/cancers13071574

Ejemplares similares

SOX2 is required independently in both stem and differentiated cells for pituitary tumorigenesis in p27-null mice
por: Moncho-Amor, Veronica, et al.
Publicado: (2021)

Sox2 Is Required Independently in Both Stem and Differentiated Cells for Pituitary Tumour Genesis in P27 Null Mice
por: Moncho-Amor, Veronica, et al.
Publicado: (2021)

High SOX9 Maintains Glioma Stem Cell Activity through a Regulatory Loop Involving STAT3 and PML
por: Aldaz, Paula, et al.
Publicado: (2022)

Reciprocal Repression between Sox3 and Snail Transcription Factors Defines Embryonic Territories at Gastrulation
por: Acloque, Hervé, et al.
Publicado: (2011)

SIX1 represses senescence and promotes SOX2-mediated cellular plasticity during tumorigenesis
por: De Lope, Cristina, et al.
Publicado: (2019)

SOX2 is sequentially required for progenitor proliferation and lineage specification in the developing pituitary
por: Goldsmith, Sam, et al.
Publicado: (2016)

p27(Kip1) Directly Represses Sox2 during Embryonic Stem Cell Differentiation
por: Li, Han, et al.
Publicado: (2012)

mTOR inhibition decreases SOX2-SOX9 mediated glioma stem cell activity and temozolomide resistance
por: Garros-Regulez, Laura, et al.
Publicado: (2016)

Impact of Chaperone-Mediated Autophagy in Brain Aging: Neurodegenerative Diseases and Glioblastoma
por: Auzmendi-Iriarte, Jaione, et al.
Publicado: (2021)

PR-LncRNA signature regulates glioma cell activity through expression of SOX factors
por: Torres-Bayona, Sergio, et al.
Publicado: (2018)

Chaperone-Mediated Autophagy Controls Proteomic and Transcriptomic Pathways to Maintain Glioma Stem Cell Activity
por: Auzmendi-Iriarte, Jaione, et al.
Publicado: (2022)

Author Correction: PR-LncRNA signature regulates glioma cell activity through expression of SOX factors
por: Torres-Bayona, Sergio, et al.
Publicado: (2022)

Methylation of MGMT promoter does not predict response to temozolomide in patients with glioblastoma in Donostia Hospital
por: Egaña, Larraitz, et al.
Publicado: (2020)

SOX2 haploinsufficiency promotes impaired vision at advanced age
por: Moreno-Cugnon, Leire, et al.
Publicado: (2018)

Liquid Biopsy in Glioblastoma: Opportunities, Applications and Challenges
por: Saenz-Antoñanzas, Ander, et al.
Publicado: (2019)

SOX9-positive pituitary stem cells differ according to their position in the gland and maintenance of their progeny depends on context
por: Rizzoti, Karine, et al.
Publicado: (2023)

Characterization of a new small-molecule inhibitor of HDAC6 in glioblastoma
por: Auzmendi-Iriarte, Jaione, et al.
Publicado: (2020)

The cortical hem lacks stem cell potential despite expressing SOX9 and HOPX
por: Caramello, Alessia, et al.
Publicado: (2022)

SOX9 Triggers Different Epithelial to Mesenchymal Transition States to Promote Pancreatic Cancer Progression
por: Carrasco-Garcia, Estefania, et al.
Publicado: (2022)

SOX9 promotes tumor progression through the axis BMI1-p21(CIP)
por: Aldaz, Paula, et al.
Publicado: (2020)

Studies of mice deleted for Sox3 and uc482: relevance to X-linked hypoparathyroidism
por: Gaynor, Katherine U, et al.
Publicado: (2020)

Targeting SOX2 as a Therapeutic Strategy in Glioblastoma
por: Garros-Regulez, Laura, et al.
Publicado: (2016)

Stem cell factor Sox2 and its close relative Sox3 have differentiation functions in oligodendrocytes
por: Hoffmann, Stephanie A., et al.
Publicado: (2014)

Congenital Hydrocephalus and Abnormal Subcommissural Organ Development in Sox3 Transgenic Mice
por: Lee, Kristie, et al.
Publicado: (2012)

Neural Differentiation of Mouse Embryonic Stem Cells—An in vitro Approach to Profile DNA Methylation of Reprogramming Factor Sox2-SRR2
por: Batool, Sajida, et al.
Publicado: (2021)

The rates of adult neurogenesis and oligodendrogenesis are linked to cell cycle regulation through p27-dependent gene repression of SOX2
por: Domingo-Muelas, Ana, et al.
Publicado: (2023)

Targeting Myotonic Dystrophy Type 1 with Metformin
por: García-Puga, Mikel, et al.
Publicado: (2022)

Oxidative stress induces the acquisition of cancer stem-like phenotype in breast cancer detectable by using a Sox2 regulatory region-2 (SRR2) reporter
por: Gopal, Keshav, et al.
Publicado: (2015)

Oncogenic activity of SOX1 in glioblastoma
por: Garcia, Idoia, et al.
Publicado: (2017)

Characterization of Fibrinogen Binding by Glycoproteins Srr1 and Srr2 of Streptococcus agalactiae
por: Seo, Ho Seong, et al.
Publicado: (2013)

SOX9-regulated cell plasticity in colorectal metastasis is attenuated by rapamycin
por: Carrasco-Garcia, Estefania, et al.
Publicado: (2016)

Triple negative breast cancers comprise a highly tumorigenic cell subpopulation detectable by its high responsiveness to a Sox2 regulatory region 2 (SRR2) reporter
por: Jung, Karen, et al.
Publicado: (2015)

Myotonic Dystrophy type 1 cells display impaired metabolism and mitochondrial dysfunction that are reversed by metformin
por: García-Puga, Mikel, et al.
Publicado: (2020)

Tbx6-dependent Sox2 regulation determines neural vs mesodermal fate in axial stem cells
por: Takemoto, Tatsuya, et al.
Publicado: (2011)

SOX2 and SOX21 in Lung Epithelial Differentiation and Repair
por: Eenjes, Evelien, et al.
Publicado: (2022)

Failure of SOX9 Regulation in 46XY Disorders of Sex Development with SRY, SOX9 and SF1 Mutations
por: Knower, Kevin C., et al.
Publicado: (2011)

Increased gene dosage of Ink4/Arf and p53 delays age-associated central nervous system functional decline
por: Carrasco-Garcia, Estefania, et al.
Publicado: (2015)

Nestin-Cre Mice Are Affected by Hypopituitarism, Which Is Not Due to Significant Activity of the Transgene in the Pituitary Gland
por: Galichet, Christophe, et al.
Publicado: (2010)

Mobilized Adult Pituitary Stem Cells Contribute to Endocrine Regeneration in Response to Physiological Demand
por: Rizzoti, Karine, et al.
Publicado: (2013)

Sox2 Uses Multiple Domains to Associate with Proteins Present in Sox2-Protein Complexes
por: Cox, Jesse L., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_bfekus7d5mceqqg6fg00ekpbii