Somatic Mutation Profiling in the Liquid Biopsy and Clinical Analysis of Hereditary and Familial Pancreatic Cancer Cases Reveals KRAS Negativity and a Longer Overall Survival

SIMPLE SUMMARY: Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis. KRAS mutations occur in up to 95% of cases and render the tumor resistant to many types of therapy. Therefore, these patients are treated with traditional cytotoxic agents, according to guidelines. The familial or heredita...

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Detalles Bibliográficos
Autores principales: Earl, Julie, Barreto, Emma, Castillo, María E., Fuentes, Raquel, Rodríguez-Garrote, Mercedes, Ferreiro, Reyes, Reguera, Pablo, Muñoz, Gloria, Garcia-Seisdedos, David, López, Jorge Villalón, Sainz, Bruno, Malats, Nuria, Carrato, Alfredo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038004/
https://www.ncbi.nlm.nih.gov/pubmed/33807330
http://dx.doi.org/10.3390/cancers13071612

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038004/
https://www.ncbi.nlm.nih.gov/pubmed/33807330
http://dx.doi.org/10.3390/cancers13071612

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