Cargando…
Diphenyl-Methane Based Thyromimetic Inhibitors for Transthyretin Amyloidosis
Thyromimetics, whose physicochemical characteristics are analog to thyroid hormones (THs) and their derivatives, are promising candidates as novel therapeutics for neurodegenerative and metabolic pathologies. In particular, sobetirome (GC-1), one of the initial halogen-free thyromimetics, and newly...
Autores principales: | Kim, Bokyung, Ko, Young Ho, Runfola, Massimiliano, Rapposelli, Simona, Ortore, Gabriella, Chiellini, Grazia, Kim, Jin Hae |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038088/ https://www.ncbi.nlm.nih.gov/pubmed/33800546 http://dx.doi.org/10.3390/ijms22073488 |
Ejemplares similares
-
Collecting data through high throughput in vitro early toxicity and off-target liability assays to rapidly identify limitations of novel thyromimetics
por: Runfola, Massimiliano, et al.
Publicado: (2020) -
Thyroxine metabolite-derived 3-iodothyronamine (T1AM) and synthetic analogs as efficient suppressors of transthyretin amyloidosis
por: Kim, Bokyung, et al.
Publicado: (2023) -
New Multitarget Approaches in the War Against Glioblastoma: A Mini-Perspective
por: Sestito, Simona, et al.
Publicado: (2018) -
Selective Thyroid Hormone Receptor-Beta (TRβ) Agonists: New Perspectives for the Treatment of Metabolic and Neurodegenerative Disorders
por: Saponaro, Federica, et al.
Publicado: (2020) -
SUN-717 SG-2 a Novel Multi-Target Directed Ligand (MTDL) for the Treatment of Neurodegenerative Diseases (NDDS)
por: Sestito, Simona, et al.
Publicado: (2020)