Conformation-Specific Inhibitory Anti-MMP-7 Monoclonal Antibody Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Chemotherapeutic Cell Kill

SIMPLE SUMMARY: Extracellular matrix remodeling enzymes are dysregulated in several pathologies. Our aim was to generate a unique function blocking monoclonal antibody against one such cancer-associated enzyme, matrix metalloproteinase 7 (MMP-7). We generated GSM-192, with high affinity and specific...

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Detalles Bibliográficos
Autores principales: Mohan, Vishnu, Gaffney, Jean P., Solomonov, Inna, Levin, Maxim, Klepfish, Mordehay, Akbareian, Sophia, Grünwald, Barbara, Dym, Orly, Eisenstein, Miriam, Yu, Kenneth H., Kelsen, David P., Krüger, Achim, Edwards, Dylan R., Sagi, Irit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038143/
https://www.ncbi.nlm.nih.gov/pubmed/33918254
http://dx.doi.org/10.3390/cancers13071679

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038143/
https://www.ncbi.nlm.nih.gov/pubmed/33918254
http://dx.doi.org/10.3390/cancers13071679

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