C-N Bond Formation by Consecutive Continuous-Flow Reductions towards A Medicinally Relevant Piperazine Derivative

A new, continuous-flow consecutive reduction method was developed for the C-N bond formation in the synthesis of the key intermediate of the antipsychotic drug cariprazine. The two-step procedure consists of a DIBAL-H mediated selective ester reduction conducted in a novel, miniature alternating dia...

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Detalles Bibliográficos
Autores principales: Fülöp, Zsolt, Bana, Péter, Greiner, István, Éles, János
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038289/
https://www.ncbi.nlm.nih.gov/pubmed/33918489
http://dx.doi.org/10.3390/molecules26072040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038289/
https://www.ncbi.nlm.nih.gov/pubmed/33918489
http://dx.doi.org/10.3390/molecules26072040

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