Nordihydroguaiaretic Acid as a Novel Substrate and Inhibitor of Catechol O-Methyltransferase Modulates 4-Hydroxyestradiol-Induced Cyto- and Genotoxicity in MCF-7 Cells

Nordihydroguaiaretic acid (NDGA) is a major lignan metabolite found in Larrea spp., which are widely used in South America to treat various diseases. In breast tissue, estradiol is metabolized to the catechol estrogens such as 4-hydroxyestradiol (4-OHE(2)), which have been proposed to be cancer init...

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Detalles Bibliográficos
Autores principales: Kim, Jin-Hee, Lee, Jimin, Jeong, Hyesoo, Bang, Mi Seo, Jeong, Jin-Hyun, Chang, Minsun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038350/
https://www.ncbi.nlm.nih.gov/pubmed/33916785
http://dx.doi.org/10.3390/molecules26072060

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038350/
https://www.ncbi.nlm.nih.gov/pubmed/33916785
http://dx.doi.org/10.3390/molecules26072060

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