Role for the Histone Demethylase KDM4B in Rhabdomyosarcoma via CDK6 and CCNA2: Compensation by KDM4A and Apoptotic Response of Targeting Both KDM4B and KDM4A

SIMPLE SUMMARY: Rhabdomyosarcomas (RMS) are soft tissue sarcomas predominant in the pediatric age range. Current standard multi-modal treatments can result in severe life-long side-effects across all subtypes and dismal outcomes in RMS patients classified as high-risk. There is an urgent need to fin...

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Detalles Bibliográficos
Autores principales: Walters, Zoë S., Aladowicz, Ewa, Villarejo-Balcells, Barbara, Nugent, Gary, Selfe, Joanna L., Eve, Paul, Blagg, Julian, Rossanese, Olivia, Shipley, Janet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038694/
https://www.ncbi.nlm.nih.gov/pubmed/33917420
http://dx.doi.org/10.3390/cancers13071734

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038694/
https://www.ncbi.nlm.nih.gov/pubmed/33917420
http://dx.doi.org/10.3390/cancers13071734

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