Transcription factor competition at the γ-globin promoters controls hemoglobin switching

BCL11A, the major regulator of HbF(α(2)γ(2)) level, represses γ-globin expression through direct promoter binding in adult erythroid cells in a switch to adult-type HbA (α(2)β(2)). To uncover how BCL11A initiates repression, we used CRISPR/Cas9, dCas9, dCas9-KRAB, and dCas9-VP64 screens to dissect t...

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Detalles Bibliográficos
Autores principales: Liu, Nan, Xu, Shuqian, Yao, Qiuming, Zhu, Qian, Kai, Yan, Hsu, Jonathan Y., Sakon, Phraew, Pinello, Luca, Yuan, Guo-Cheng, Bauer, Daniel E., Orkin, Stuart H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038971/
https://www.ncbi.nlm.nih.gov/pubmed/33649594
http://dx.doi.org/10.1038/s41588-021-00798-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038971/
https://www.ncbi.nlm.nih.gov/pubmed/33649594
http://dx.doi.org/10.1038/s41588-021-00798-y

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