Cocaine-related DNA methylation in caudate neurons alters 3D chromatin structure of the IRXA gene cluster.

Epigenetic mechanisms, like those involving DNA methylation, are thought to mediate the relationship between chronic cocaine dependence and molecular changes in addiction-related neurocircuitry but have been understudied in human brain. We initially used reduced representation bisulfite sequencing (...

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Detalles Bibliográficos
Autores principales: Vaillancourt, Kathryn, Yang, Jennie, Chen, Gary G., Yerko, Volodymyr, Théroux, Jean-François, Aouabed, Zahia, Lopez, Alberto, Thibeault, Kimberly C., Calipari, Erin S., Labonté, Benoit, Mechawar, Naguib, Ernst, Carl, Nagy, Corina, Forne, Thierry, Nestler, Eric J., Mash, Deborah C., Turecki, Gustavo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039060/
https://www.ncbi.nlm.nih.gov/pubmed/33046833
http://dx.doi.org/10.1038/s41380-020-00909-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039060/
https://www.ncbi.nlm.nih.gov/pubmed/33046833
http://dx.doi.org/10.1038/s41380-020-00909-x

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