uhrf1 and dnmt1 Loss Induces an Immune Response in Zebrafish Livers Due to Viral Mimicry by Transposable Elements

Activation of transposable elements (TEs) can cause cellular damage. Cytoplasmic nucleic acid sensing pathways evolved to detect pathogens, but can also serve to cull cells with inappropriate TE activation as TEs can be viral mimetics. Epigenetic silencing of TEs is mediated in part by DNA methylati...

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Detalles Bibliográficos
Autores principales: Magnani, Elena, Macchi, Filippo, Madakashira, Bhavani P., Zhang, Chi, Alaydaroos, Fatima, Sadler, Kirsten C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039153/
https://www.ncbi.nlm.nih.gov/pubmed/33854502
http://dx.doi.org/10.3389/fimmu.2021.627926

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039153/
https://www.ncbi.nlm.nih.gov/pubmed/33854502
http://dx.doi.org/10.3389/fimmu.2021.627926

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