Magnitude of Off-Target Allo-HLA Reactivity by Third-Party Donor-Derived Virus-Specific T Cells Is Dictated by HLA-Restriction

T-cell products derived from third-party donors are clinically applied, but harbor the risk of off-target toxicity via induction of allo-HLA cross-reactivity directed against mismatched alleles. We used third-party donor-derived virus-specific T cells as model to investigate whether virus-specificit...

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Detalles Bibliográficos
Autores principales: Huisman, Wesley, Leboux, Didier A. T., van der Maarel, Lieve E., Hageman, Lois, Amsen, Derk, Falkenburg, J. H. Frederik, Jedema, Inge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039299/
https://www.ncbi.nlm.nih.gov/pubmed/33854504
http://dx.doi.org/10.3389/fimmu.2021.630440

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039299/
https://www.ncbi.nlm.nih.gov/pubmed/33854504
http://dx.doi.org/10.3389/fimmu.2021.630440

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