Subretinal Rather Than Intravitreal Adeno-Associated Virus–Mediated Delivery of a Complement Alternative Pathway Inhibitor Is Effective in a Mouse Model of RPE Damage

PURPOSE: The risk for age-related macular degeneration has been tied to an overactive complement system. Despite combined attempts by academia and industry to develop therapeutics that modulate the complement response, particularly in the late geographic atrophy form of advanced AMD, to date, there...

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Detalles Bibliográficos
Autores principales: Annamalai, Balasubramaniam, Parsons, Nathaniel, Nicholson, Crystal, Obert, Elisabeth, Jones, Bryan, Rohrer, Bärbel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2021
Materias:
Retina
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039473/
https://www.ncbi.nlm.nih.gov/pubmed/33830174
http://dx.doi.org/10.1167/iovs.62.4.11

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039473/
https://www.ncbi.nlm.nih.gov/pubmed/33830174
http://dx.doi.org/10.1167/iovs.62.4.11

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