Cargando…

Roxithromycin attenuates inflammation via modulation of RAGE-influenced calprotectin expression in a neutrophilic asthma model

BACKGROUND: Roxithromycin (RXM), a macrolide antibiotic, exhibits anti-asthmatic effects, but its specific mechanism of action remains elusive. We evaluated the effects of RXM on airway inflammation, the expression of calprotectin, and the activity of the receptor of advanced glycation end products...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gu, Xiaofei, Shu, Danni, Ying, Songmin, Dai, Yuanrong, Zhang, Qi, Chen, Xinmiao, Chen, Huijun, Dai, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AME Publishing Company 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039670/ https://www.ncbi.nlm.nih.gov/pubmed/33850891 http://dx.doi.org/10.21037/atm-21-859

Ejemplares similares

Pathological Roles of Neutrophil-Mediated Inflammation in Asthma and Its Potential for Therapy as a Target
por: Gao, Han, et al.
Publicado: (2017)

Roxithromycin-Associated Acute Thrombocytopenia
por: Rossi, Marco, et al.
Publicado: (2021)

Roxithromycin treatment inhibits TGF-β1-induced activation of ERK and AKT and down-regulation of Caveolin-1 in rat airway smooth muscle cells
por: Dai, Yuanrong, et al.
Publicado: (2014)

Baicalein attenuates OVA-induced allergic airway inflammation through the inhibition of the NF-κB signaling pathway
por: Xu, Tingting, et al.
Publicado: (2019)

Suppression of matrix metalloproteinase-9 production from neutrophils by a macrolide antibiotic, roxithromycin, in vitro.
por: Kanai, Ken-Ichi, et al.
Publicado: (2004)

sRAGE alleviates neutrophilic asthma by blocking HMGB1/RAGE signalling in airway dendritic cells
por: Zhang, Fang, et al.
Publicado: (2017)

Use of clarithromycin and roxithromycin and risk of cardiac death: cohort study
por: Svanström, Henrik, et al.
Publicado: (2014)

Inhibition of sulfur mustard-induced cytotoxicity and inflammation by the macrolide antibiotic roxithromycin in human respiratory epithelial cells
por: Gao, Xiugong, et al.
Publicado: (2007)

Effect of Low-Dose, Long-Term Roxithromycin on Airway Inflammation and Remodeling of Stable Noncystic Fibrosis Bronchiectasis
por: Liu, Jifeng, et al.
Publicado: (2014)

Drug-drug interaction of acetaminophen and roxithromycin with the cocktail of cytochrome P450 and hepatotoxicity in rats
por: Liu, Xiang, et al.
Publicado: (2020)

Calprotectin as a New Sensitive Marker of Neutrophilic Inflammation in Patients with Bronchiolitis Obliterans
por: Jerkic, S. P., et al.
Publicado: (2020)

A double-blind, randomised, placebo-controlled study of roxithromycin and doxycycline combination, roxithromycin alone, or matching placebo for 12 weeks in adults with frequent exacerbations of chronic obstructive pulmonary disease
por: Shafuddin, Eskandarain, et al.
Publicado: (2015)

Influence of a macrolide antibiotic, roxithromycin, on mast cell growth and activation in vitro.
por: Shimane, T, et al.
Publicado: (2001)

Deletion of Shp2 in bronchial epithelial cells impairs IL-25 production in vitro, but has minor influence on asthmatic inflammation in vivo
por: Qiu, Zhangwei, et al.
Publicado: (2017)

Enhanced antibacterial activity of roxithromycin loaded pegylated poly lactide-co-glycolide nanoparticles
por: Koopaei, Mona Noori, et al.
Publicado: (2012)

Case Series Analysis of New Zealand Reports of Rapid Intense Potentiation of Warfarin by Roxithromycin
por: Savage, Ruth L., et al.
Publicado: (2018)

Clinical features of 64 patients (outside Hubei) with COVID-19 in Wenzhou, China
por: Qiu, Zhangwei, et al.
Publicado: (2020)

Inhibitory action of a macrolide antibiotic, roxithromycin, on co-stimulatory molecule expressions in vitro and in vivo.
por: Suzuki, Mayumi, et al.
Publicado: (2002)

Suppressive activity of a macrolide antibiotic, roxithromycin, on pro-inflammatory cytokine production in vitro and in vivo.
por: Suzaki, H, et al.
Publicado: (1999)

Roxithromycin monotherapy inducing a partial response in a patient with myeloma: a case report
por: Chai, Kern Y., et al.
Publicado: (2018)

Azithromycin and Roxithromycin define a new family of “senolytic” drugs that target senescent human fibroblasts
por: Ozsvari, Bela, et al.
Publicado: (2018)

Leptin, ghrelin and calprotectin: inflammatory markers in childhood asthma?
por: Cobanoglu, Nazan, et al.
Publicado: (2013)

Serum Calprotectin Is a Potential Marker in Patients with Asthma
por: Lee, Yun-Gi, et al.
Publicado: (2020)

Neutrophil calprotectin identifies severe pulmonary disease in COVID-19
por: Shi, Hui, et al.
Publicado: (2020)

Suppressive activity of a macrolide antibiotic, roxithromycin on co-stimulatory molecule expression on mouse splenocytes in vivo.
por: Kawazu, K, et al.
Publicado: (2000)

Clarification of the internal structure and factors of poor dissolution of substandard roxithromycin tablets by near-infrared chemical imaging
por: Sakuda, Mirai, et al.
Publicado: (2021)

The Role of Neutrophil Proteins on the Amyloid Beta-RAGE Axis
por: Stock, Amanda J., et al.
Publicado: (2016)

RAGE (Receptor for Advanced Glycation Endproducts), RAGE Ligands, and their role in Cancer and Inflammation
por: Sparvero, Louis J, et al.
Publicado: (2009)

The receptor RAGE: Bridging inflammation and cancer
por: Riehl, Astrid, et al.
Publicado: (2009)

Effects of Pelargonium sidoides extract vs roxithromycin on chemokine levels in nasal secretions of patients with uncomplicated acute rhinosinusitis
por: Perić, Aleksandar, et al.
Publicado: (2020)

Piperlongumine reduces ovalbumin-induced asthma and airway inflammation by regulating nuclear factor-κB activation
por: Lu, Chun, et al.
Publicado: (2019)

RAGE contributes to allergen driven severe neutrophilic airway inflammation via NLRP3 inflammasome activation in mice
por: Killian, Katherine N., et al.
Publicado: (2023)

Elevated calprotectin levels reveal bowel inflammation in spondyloarthritis
por: Cypers, H, et al.
Publicado: (2016)

COVID-19 and intestinal inflammation: Role of fecal calprotectin
por: Ojetti, Veronica, et al.
Publicado: (2020)

Faecal calprotectin indicates intestinal inflammation in COVID-19
por: Effenberger, Maria, et al.
Publicado: (2020)

miR-3934 regulates the apoptosis and secretion of inflammatory cytokines of basophils via targeting RAGE in asthma
por: Dou, Liyan, et al.
Publicado: (2022)

Role of RAGE in obesity-induced adipose tissue inflammation and insulin resistance
por: Feng, Ziqian, et al.
Publicado: (2021)

Dihydromyricetin Attenuates Depressive-like Behaviors in Mice by Inhibiting the AGE-RAGE Signaling Pathway
por: Huang, Jun, et al.
Publicado: (2022)

Calprotectin Levels and Neutrophil Count Are Prognostic Markers of Mortality in COVID-19 Patients
por: Cardiero, Giovanna, et al.
Publicado: (2022)

Regulation of RAGE for Attenuating Progression of Diabetic Vascular Complications
por: Win, Myat Thu Thu, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_n56mdsdobfa26e76mqlk4rbea4