Cargando…

c-MYC-directed NRF2 drives malignant progression of head and neck cancer via glucose-6-phosphate dehydrogenase and transketolase activation

Rationale: NRF2, a redox sensitive transcription factor, is up-regulated in head and neck squamous cell carcinoma (HNSCC), however, the associated impact and regulatory mechanisms remain unclear. Methods: The protein expression of NRF2 in HNSCC specimens was examined by IHC. The regulatory effect of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tang, Ya-Chu, Hsiao, Jenn-Ren, Jiang, Shih-Sheng, Chang, Jang-Yang, Chu, Pei-Yi, Liu, Ko-Jiunn, Fang, Hsun-Lang, Lin, Li-Mei, Chen, Huang-Hui, Huang, Yen-Wen, Chen, Yu-Tsen, Tsai, Fang-Yu, Lin, Su-Fang, Chuang, Yung-Jen, Kuo, Ching-Chuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039948/ https://www.ncbi.nlm.nih.gov/pubmed/33859744 http://dx.doi.org/10.7150/thno.53417

Ejemplares similares

Evidence of Diradicals Involved in the Yeast Transketolase Catalyzed Keto‐Transferring Reactions
por: Hsu, Ning‐Shian, et al.
Publicado: (2018)

Transketolase in human Müller cells is critical to resist light stress through the pentose phosphate and NRF2 pathways
por: Chen, Yingying, et al.
Publicado: (2022)

Glucose-6-phosphate dehydrogenase and transketolase modulate breast cancer cell metabolic reprogramming and correlate with poor patient outcome
por: Benito, Adrián, et al.
Publicado: (2017)

Cigarette Smoke Exposure Increases Glucose-6-phosphate Dehydrogenase, Autophagy, Fibrosis, and Senescence in Kidney Cells In Vitro and In Vivo
por: Liu, Wen-Chih, et al.
Publicado: (2022)

A novel NRF2/ARE inhibitor gossypol induces cytotoxicity and sensitizes chemotherapy responses in chemo-refractory cancer cells
por: Tang, Ya-Chu, et al.
Publicado: (2021)

The human transketolase-like proteins TKTL1 and TKTL2 are bona fide transketolases
por: Deshpande, Gaurang P., et al.
Publicado: (2019)

Inhibition of Transketolase Improves the Prognosis of Colorectal Cancer
por: Zhang, Linhao, et al.
Publicado: (2022)

Correspondence: Measurement of erythrocyte transketolase activity
por: King, Donald E., et al.
Publicado: (1983)

New Role of Water in Transketolase Catalysis
por: Solovjeva, Olga N.
Publicado: (2023)

Transketolase promotes colorectal cancer metastasis through regulating AKT phosphorylation
por: Li, Minle, et al.
Publicado: (2022)

Function of the pentose phosphate pathway and its key enzyme, transketolase, in the regulation of the meiotic cell cycle in oocytes
por: Kim, Yunna, et al.
Publicado: (2012)

A first immunohistochemistry study of transketolase and transketolase-like 1 expression in canine hyperplastic and neoplastic mammary lesions
por: Burrai, Giovanni Pietro, et al.
Publicado: (2017)

Lactate-Dehydrogenase 5 is overexpressed in non-small cell lung cancer and correlates with the expression of the transketolase-like protein 1
por: Kayser, Gian, et al.
Publicado: (2010)

Thiol Redox Sensitivity of Two Key Enzymes of Heme Biosynthesis and Pentose Phosphate Pathways: Uroporphyrinogen Decarboxylase and Transketolase
por: McDonagh, Brian, et al.
Publicado: (2013)

The mechanism of a one-substrate transketolase reaction
por: Solovjeva, Olga N., et al.
Publicado: (2020)

A Δ38 Deletion Variant of Human Transketolase as a Model of Transketolase-Like Protein 1 Exhibits No Enzymatic Activity
por: Schneider, Stefan, et al.
Publicado: (2012)

Genotypic and phenotypic characterization of glucose-6-phosphate dehydrogenase (G6PD) deficiency in Guangzhou, China
por: Li, Ziyan, et al.
Publicado: (2023)

Elevated FBXL6 expression in hepatocytes activates VRK2-transketolase-ROS-mTOR-mediated immune evasion and liver cancer metastasis in mice
por: Zhang, Jie, et al.
Publicado: (2023)

Dissecting the function of Atg1 complex in Dictyostelium autophagy reveals a connection with the pentose phosphate pathway enzyme transketolase
por: Mesquita, Ana, et al.
Publicado: (2015)

How to deal with frenemy NRF2: Targeting NRF2 for chemoprevention and cancer therapy
por: Tang, Ya-Chu, et al.
Publicado: (2023)

Erythrocyte transketolase activity measured on the Gemstar discrete analyser
por: Buttery, J. E., et al.
Publicado: (1984)

The measurement of erythrocyte transketolase activity on a discrete analyser
por: Milner, C. R., et al.
Publicado: (1982)

Structure-Based Discovery and Synthesis of Potential Transketolase Inhibitors
por: Huo, Jingqian, et al.
Publicado: (2018)

The role of transketolase and octulose in the resurrection plant Craterostigma plantagineum
por: Zhang, Qingwei, et al.
Publicado: (2016)

The influence of transketolase on lipid biosynthesis in the yeast Yarrowia lipolytica
por: Dobrowolski, Adam, et al.
Publicado: (2020)

Prognostic values of transketolase family genes in ovarian cancer
por: Zhao, Menghuang, et al.
Publicado: (2019)

Hospital Board of Directors’ Composition and Financial Performance: Empirical Evidence from Taiwan
por: Chen, Kuan-Chen, et al.
Publicado: (2021)

Revealing the Functions of the Transketolase Enzyme Isoforms in Rhodopseudomonas palustris Using a Systems Biology Approach
por: Hu, Chia-Wei, et al.
Publicado: (2011)

Itraconazole improves survival outcomes in patients with colon cancer by inducing autophagic cell death and inhibiting transketolase expression
por: Shen, Pei-Wen, et al.
Publicado: (2021)

Author Correction: Elevated FBXL6 expression in hepatocytes activates VRK2-transketolase-ROS-mTOR-mediated immune evasion and liver cancer metastasis in mice
por: Zhang, Jie, et al.
Publicado: (2023)

Novel transketolase inhibitor oroxylin A suppresses the non‐oxidative pentose phosphate pathway and hepatocellular carcinoma tumour growth in mice and patient‐derived organoids
por: Jia, Dan, et al.
Publicado: (2022)

Insight into transketolase of Pyropia haitanensis under desiccation stress based on integrative analysis of omics and transformation
por: Shi, Jianzhi, et al.
Publicado: (2019)

Transketolase Serves a Poor Prognosticator in Esophageal Cancer by Promoting Cell Invasion via Epithelial-Mesenchymal Transition
por: Chao, Yin-Kai, et al.
Publicado: (2016)

Microfluidic multi-input reactor for biocatalytic synthesis using transketolase()
por: Lawrence, James, et al.
Publicado: (2013)

Structural Analysis of an Evolved Transketolase Reveals Divergent Binding Modes
por: Affaticati, Pierre E., et al.
Publicado: (2016)

Characterisation of plasmodial transketolases and identification of potential inhibitors: an in silico study
por: Boateng, Rita Afriyie, et al.
Publicado: (2020)

Isolation and Biochemical Characterization of Recombinant Transketolase from Mycobacterium tuberculosis
por: Shcherbakova, T. A., et al.
Publicado: (2022)

Evaluation of a Novel Quantitative Test for Glucose-6-Phosphate Dehydrogenase Deficiency: Bringing Quantitative Testing for Glucose-6-Phosphate Dehydrogenase Deficiency Closer to the Patient
por: Pal, Sampa, et al.
Publicado: (2019)

Glutamine Modulates Expression and Function of Glucose 6-Phosphate Dehydrogenase via NRF2 in Colon Cancer Cells
por: Polat, Ibrahim H., et al.
Publicado: (2021)

PRMT1 Confers Resistance to Olaparib via Modulating MYC Signaling in Triple-Negative Breast Cancer
por: Hsu, Wen-Jing, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_k284348r7btdvoqnf2rp2n4nva