Deep-learning and MR images to target hypoxic habitats with evofosfamide in preclinical models of sarcoma

Rationale: Hypoxic regions (habitats) within tumors are heterogeneously distributed and can be widely variant. Hypoxic habitats are generally pan-therapy resistant. For this reason, hypoxia-activated prodrugs (HAPs) have been developed to target these resistant volumes. The HAP evofosfamide (TH-302)...

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Detalles Bibliográficos
Autores principales: Jardim-Perassi, Bruna V., Mu, Wei, Huang, Suning, Tomaszewski, Michal R., Poleszczuk, Jan, Abdalah, Mahmoud A., Budzevich, Mikalai M., Dominguez-Viqueira, William, Reed, Damon R., Bui, Marilyn M., Johnson, Joseph O., Martinez, Gary V., Gillies, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039958/
https://www.ncbi.nlm.nih.gov/pubmed/33859749
http://dx.doi.org/10.7150/thno.56595

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039958/
https://www.ncbi.nlm.nih.gov/pubmed/33859749
http://dx.doi.org/10.7150/thno.56595

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