Covalent Occlusion of the RORγt Ligand Binding Pocket Allows Unambiguous Targeting of an Allosteric Site

[Image: see text] The nuclear receptor RORγt is a key positive regulator in the differentiation and proliferation of T helper 17 (Th17) cells and the production of proinflammatory cytokines like IL-17a. Dysregulation of this pathway can result in the development of various autoimmune diseases, and i...

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Detalles Bibliográficos
Autores principales: Meijer, Femke A., van den Oetelaar, Maxime C. M., Doveston, Richard G., Sampers, Ella N. R., Brunsveld, Luc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040040/
https://www.ncbi.nlm.nih.gov/pubmed/33854703
http://dx.doi.org/10.1021/acsmedchemlett.1c00029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040040/
https://www.ncbi.nlm.nih.gov/pubmed/33854703
http://dx.doi.org/10.1021/acsmedchemlett.1c00029

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