miR-140 inhibits osteosarcoma progression by impairing USP22-mediated LSD1 stabilization and promoting p21 expression

Osteosarcoma is a bone tumor frequently diagnosed in children and young adults. Despite advances in chemotherapy and surgical resection, tumors metastasize in 30% of osteosarcoma patients. In addition, side effects caused by chemotherapeutic drugs, as well as the development of chemoresistance, high...

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Detalles Bibliográficos
Autores principales: Liu, Wei, Wang, Dunwei, Liu, Lidi, Wang, Lin, Yan, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040122/
https://www.ncbi.nlm.nih.gov/pubmed/33868787
http://dx.doi.org/10.1016/j.omtn.2021.01.029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040122/
https://www.ncbi.nlm.nih.gov/pubmed/33868787
http://dx.doi.org/10.1016/j.omtn.2021.01.029

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