Wild-type IDH1 inhibits the tumor growth through degrading HIF-α in renal cell carcinoma

The purpose of our study was to explore the effect and intrinsic mechanism of wild-type IDH1 and its substrate α-KG on renal cell carcinoma (RCC). IDH1 was observed lower expression in RCC cell lines. Phenotype experiment was carried out in the wild-type IDH1 and mutant IDH1(R132H) plasmid treated c...

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Detalles Bibliográficos
Autores principales: Chen, Song, Wang, Yejinpeng, Xiong, Yaoyi, Peng, Tianchen, Lu, Mengxin, Zhang, Lian, Guo, Zhongqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040470/
https://www.ncbi.nlm.nih.gov/pubmed/33867843
http://dx.doi.org/10.7150/ijbs.54401

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040470/
https://www.ncbi.nlm.nih.gov/pubmed/33867843
http://dx.doi.org/10.7150/ijbs.54401

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