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Substrate discrimination and quality control require each catalytic activity of TRAMP and the nuclear RNA exosome

Quality control requires discrimination between functional and aberrant species to selectively target aberrant substrates for destruction. Nuclear RNA quality control in Saccharomyces cerevisiae includes the TRAMP complex that marks RNA for decay via polyadenylation followed by helicase-dependent 3′...

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Detalles Bibliográficos
Autores principales: Das, Mom, Zattas, Dimitrios, Zinder, John C., Wasmuth, Elizabeth V., Henri, Julien, Lima, Christopher D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040639/
https://www.ncbi.nlm.nih.gov/pubmed/33782132
http://dx.doi.org/10.1073/pnas.2024846118