cGAS-STING Pathway Does Not Promote Autoimmunity in Murine Models of SLE

Detection of DNA is an important determinant of host-defense but also a driver of autoinflammatory and autoimmune diseases. Failure to degrade self-DNA in DNAseII or III(TREX1)-deficient mice results in activation of the cGAS-STING pathway. Deficiency of cGAS or STING in these models ameliorates dis...

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Detalles Bibliográficos
Autores principales: Motwani, Mona, McGowan, Jason, Antonovitch, Jennifer, Gao, Kevin MingJie, Jiang, Zhaozhao, Sharma, Shruti, Baltus, Gretchen A., Nickerson, Kevin M., Marshak-Rothstein, Ann, Fitzgerald, Katherine A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040952/
https://www.ncbi.nlm.nih.gov/pubmed/33854495
http://dx.doi.org/10.3389/fimmu.2021.605930

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040952/
https://www.ncbi.nlm.nih.gov/pubmed/33854495
http://dx.doi.org/10.3389/fimmu.2021.605930

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