Identification of small molecule allosteric modulators of 5,10-methylenetetrahydrofolate reductase (MTHFR) by targeting its unique regulatory domain

The folate and methionine cycles, constituting one-carbon metabolism, are critical pathways for cell survival. Intersecting these two cycles, 5,10-methylenetetrahydrofolate reductase (MTHFR) directs one-carbon units from the folate to methionine cycle, to be exclusively used for methionine and S-ade...

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Detalles Bibliográficos
Autores principales: Bezerra, Gustavo A., Holenstein, Alexander, Foster, William R., Xie, Bing, Hicks, Kevin G., Bürer, Céline, Lutz, Seraina, Mukherjee, Ayan, Sarkar, Dipika, Bhattacharya, Debomita, Rutter, Jared, Talukdar, Arindam, Brown, Peter J., Luo, Minkui, Shi, Lei, Froese, D. Sean, Yue, Wyatt W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editions Scientifiques Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040968/
https://www.ncbi.nlm.nih.gov/pubmed/33476699
http://dx.doi.org/10.1016/j.biochi.2021.01.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040968/
https://www.ncbi.nlm.nih.gov/pubmed/33476699
http://dx.doi.org/10.1016/j.biochi.2021.01.007

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