Loss of the abasic site sensor HMCES is synthetic lethal with the activity of the APOBEC3A cytosine deaminase in cancer cells

Analysis of cancer mutagenic signatures provides information about the origin of mutations and can inform the use of clinical therapies, including immunotherapy. In particular, APOBEC3A (A3A) has emerged as a major driver of mutagenesis in cancer cells, and its expression results in DNA damage and s...

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Detalles Bibliográficos
Autores principales: Biayna, Josep, Garcia-Cao, Isabel, Álvarez, Miguel M., Salvadores, Marina, Espinosa-Carrasco, Jose, McCullough, Marcel, Supek, Fran, Stracker, Travis H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041192/
https://www.ncbi.nlm.nih.gov/pubmed/33788831
http://dx.doi.org/10.1371/journal.pbio.3001176

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041192/
https://www.ncbi.nlm.nih.gov/pubmed/33788831
http://dx.doi.org/10.1371/journal.pbio.3001176

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