Tunable Methacrylamides for Covalent Ligand Directed Release Chemistry

[Image: see text] Targeted covalent inhibitors are an important class of drugs and chemical probes. However, relatively few electrophiles meet the criteria for successful covalent inhibitor design. Here we describe α-substituted methacrylamides as a new class of electrophiles suitable for targeted c...

Descripción completa

Detalles Bibliográficos
Autores principales: Reddi, Rambabu N., Resnick, Efrat, Rogel, Adi, Rao, Boddu Venkateswara, Gabizon, Ronen, Goldenberg, Kim, Gurwicz, Neta, Zaidman, Daniel, Plotnikov, Alexander, Barr, Haim, Shulman, Ziv, London, Nir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041284/
https://www.ncbi.nlm.nih.gov/pubmed/33761747
http://dx.doi.org/10.1021/jacs.0c10644

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041284/
https://www.ncbi.nlm.nih.gov/pubmed/33761747
http://dx.doi.org/10.1021/jacs.0c10644

Ejemplares similares