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Tunable Methacrylamides for Covalent Ligand Directed Release Chemistry
[Image: see text] Targeted covalent inhibitors are an important class of drugs and chemical probes. However, relatively few electrophiles meet the criteria for successful covalent inhibitor design. Here we describe α-substituted methacrylamides as a new class of electrophiles suitable for targeted c...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041284/ https://www.ncbi.nlm.nih.gov/pubmed/33761747 http://dx.doi.org/10.1021/jacs.0c10644 |