Cargando…

Profiling the Tox21 Chemical Collection for Acetylcholinesterase Inhibition

BACKGROUND: Inhibition of acetylcholinesterase (AChE), a biomarker of organophosphorous and carbamate exposure in environmental and occupational human health, has been commonly used to identify potential safety liabilities. So far, many environmental chemicals, including drug candidates, food additi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Shuaizhang, Zhao, Jinghua, Huang, Ruili, Travers, Jameson, Klumpp-Thomas, Carleen, Yu, Wenbo, MacKerell, Alexander D., Sakamuru, Srilatha, Ooka, Masato, Xue, Fengtian, Sipes, Nisha S., Hsieh, Jui-Hua, Ryan, Kristen, Simeonov, Anton, Santillo, Michael F., Xia, Menghang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Environmental Health Perspectives 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041433/ https://www.ncbi.nlm.nih.gov/pubmed/33844597 http://dx.doi.org/10.1289/EHP6993

Ejemplares similares

Identification of Compounds for Butyrylcholinesterase Inhibition
por: Li, Shuaizhang, et al.
Publicado: (2021)

Use of Tox21 Screening Data to Evaluate the COVID-19 Drug Candidates for Their Potential Toxic Effects and Related Pathways
por: Sakamuru, Srilatha, et al.
Publicado: (2022)

Modelling the Tox21 10 K chemical profiles for in vivo toxicity prediction and mechanism characterization
por: Huang, Ruili, et al.
Publicado: (2016)

Identification of environmental chemicals that activate p53 signaling after in vitro metabolic activation
por: Ooka, Masato, et al.
Publicado: (2022)

Identification of Angiogenesis Inhibitors Using a Co-culture Cell Model in a High-Content and High-Throughput Screening Platform
por: Li, Shuaizhang, et al.
Publicado: (2017)

Expanding biological space coverage enhances the prediction of drug adverse effects in human using in vitro activity profiles
por: Huang, Ruili, et al.
Publicado: (2018)

Limited Chemical Structural Diversity Found to Modulate Thyroid Hormone Receptor in the Tox21 Chemical Library
por: Paul-Friedman, Katie, et al.
Publicado: (2019)

Using Tox21 High-Throughput Screening Assays for the Evaluation of Botanical and Dietary Supplements
por: Hubbard, Troy D., et al.
Publicado: (2019)

Mining of high throughput screening database reveals AP-1 and autophagy pathways as potential targets for COVID-19 therapeutics
por: Zhu, Hu, et al.
Publicado: (2021)

Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway
por: Huang, Ruili, et al.
Publicado: (2014)

Bioactivity Signatures of Drugs vs. Environmental Chemicals Revealed by Tox21 High-Throughput Screening Assays
por: Ngan, Deborah K., et al.
Publicado: (2019)

High-Throughput Screening to Predict Chemical-Assay Interference
por: Borrel, Alexandre, et al.
Publicado: (2020)

Identification of Compounds That Inhibit Estrogen-Related Receptor Alpha Signaling Using High-Throughput Screening Assays
por: Lynch, Caitlin, et al.
Publicado: (2019)

Real-time cell toxicity profiling of Tox21 10K compounds reveals cytotoxicity dependent toxicity pathway linkage
por: Hsieh, Jui-Hua, et al.
Publicado: (2017)

Correction: Real-time cell toxicity profiling of Tox21 10K compounds reveals cytotoxicity dependent toxicity pathway linkage
por: Hsieh, Jui-Hua, et al.
Publicado: (2017)

MON-032 Identification of Estrogen-Related Receptor Alpha Inhibitors from the Tox21 10K Compound Collection
por: Lynch, Caitlin, et al.
Publicado: (2019)

Profiling of the Tox21 Chemical Collection for Mitochondrial Function to Identify Compounds that Acutely Decrease Mitochondrial Membrane Potential
por: Attene-Ramos, Matias S., et al.
Publicado: (2014)

HTS-Compatible β-Lactamase Transcriptional Reporter Gene Assay for Interrogating the Heat Shock Response Pathway
por: Hancock, Michael K, et al.
Publicado: (2009)

Development and Application of Human Renal Proximal Tubule Epithelial Cells for Assessment of Compound Toxicity
por: Li, Shuaizhang, et al.
Publicado: (2017)

hERG Blockade Prediction by Combining Site Identification by Ligand Competitive Saturation and Physicochemical Properties
por: Goel, Himanshu, et al.
Publicado: (2022)

Predictive modeling of biological responses in the rat liver using in vitro Tox21 bioactivity: Benefits from high-throughput toxicokinetics
por: Ring, Caroline, et al.
Publicado: (2021)

Two-Dimensional Cellular and Three-Dimensional Bio-Printed Skin Models to Screen Topical-Use Compounds for Irritation Potential
por: Wei, Zhengxi, et al.
Publicado: (2020)

Drug repurposing screen identifies lestaurtinib amplifies the ability of the poly (ADP-ribose) polymerase 1 inhibitor AG14361 to kill breast cancer associated gene-1 mutant and wild type breast cancer cells
por: Vazquez-Ortiz, Guelaguetza, et al.
Publicado: (2014)

Identification of Selective CYP3A7 and CYP3A4 Substrates and Inhibitors Using a High-Throughput Screening Platform
por: Kabir, Md, et al.
Publicado: (2022)

Comment on “On the Utility of ToxCast™ and ToxPi as Methods for Identifying New Obesogens”
por: Houck, Keith A., et al.
Publicado: (2017)

Identification of small molecule compounds that inhibit the HIF-1 signaling pathway
por: Xia, Menghang, et al.
Publicado: (2009)

Identification of repurposed small molecule drugs for chordoma therapy
por: Xia, Menghang, et al.
Publicado: (2013)

Identifying Attributes That Influence In Vitro-to-In Vivo Concordance by Comparing In Vitro Tox21 Bioactivity Versus In Vivo DrugMatrix Transcriptomic Responses Across 130 Chemicals
por: Klaren, William D, et al.
Publicado: (2019)

Profiling 976 ToxCast Chemicals across 331 Enzymatic and Receptor Signaling Assays
por: Sipes, Nisha S., et al.
Publicado: (2013)

Comprehensive Analyses and Prioritization of Tox21 10K Chemicals Affecting Mitochondrial Function by in-Depth Mechanistic Studies
por: Xia, Menghang, et al.
Publicado: (2018)

Application of In Vitro Metabolism Activation in High-Throughput Screening
por: Ooka, Masato, et al.
Publicado: (2020)

Lestaurtinib induces DNA damage that is related to estrogen receptor activation
por: Ooka, Masato, et al.
Publicado: (2022)

Quantitative Chemotherapeutic Profiling of Gynecologic Cancer Cell Lines Using Approved Drugs and Bioactive Compounds()
por: Gorshkov, Kirill, et al.
Publicado: (2018)

Sampling of Organic Solutes in Aqueous and Heterogeneous Environments Using Oscillating Excess Chemical Potentials in Grand Canonical-like Monte Carlo-Molecular Dynamics Simulations
por: Lakkaraju, Sirish Kaushik, et al.
Publicado: (2014)

Computational Fragment-Based Binding Site Identification by Ligand Competitive Saturation
por: Guvench, Olgun, et al.
Publicado: (2009)

Balancing the Interactions of Ions, Water, and DNA in the Drude Polarizable Force Field
por: Savelyev, Alexey, et al.
Publicado: (2014)

Differential Impact of the Monovalent Ions Li(+), Na(+), K(+), and Rb(+) on DNA Conformational Properties
por: Savelyev, Alexey, et al.
Publicado: (2014)

Discovery of beta-lactamase CMY-10 inhibitors for combination therapy against multi-drug resistant Enterobacteriaceae
por: Parvaiz, Nousheen, et al.
Publicado: (2021)

Development of an assay pipeline for the discovery of novel small molecule inhibitors of human glutathione peroxidases GPX1 and GPX4
por: Cheff, Dorian M., et al.
Publicado: (2023)

Chemical Genomics Profiling of Environmental Chemical Modulation of Human Nuclear Receptors
por: Huang, Ruili, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_iim8eiqk25qiegf4v2uj02d3fv