Sigma-1 and dopamine D2/D3 receptor occupancy of pridopidine in healthy volunteers and patients with Huntington disease: a [(18)F] fluspidine and [(18)F] fallypride PET study

PURPOSE: Pridopidine is an investigational drug for Huntington disease (HD). Pridopidine was originally thought to act as a dopamine stabilizer. However, pridopidine shows highest affinity to the sigma-1 receptor (S1R) and enhances neuroprotection via the S1R in preclinical studies. Using [(18)F] fl...

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Detalles Bibliográficos
Autores principales: Grachev, Igor D., Meyer, Philipp M., Becker, Georg A., Bronzel, Marcus, Marsteller, Doug, Pastino, Gina, Voges, Ole, Rabinovich, Laura, Knebel, Helena, Zientek, Franziska, Rullmann, Michael, Sattler, Bernhard, Patt, Marianne, Gerhards, Thilo, Strauss, Maria, Kluge, Andreas, Brust, Peter, Savola, Juha-Matti, Gordon, Mark F., Geva, Michal, Hesse, Swen, Barthel, Henryk, Hayden, Michael R., Sabri, Osama
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041674/
https://www.ncbi.nlm.nih.gov/pubmed/32995944
http://dx.doi.org/10.1007/s00259-020-05030-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041674/
https://www.ncbi.nlm.nih.gov/pubmed/32995944
http://dx.doi.org/10.1007/s00259-020-05030-3

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