A deimmunized and pharmacologically optimized Toll-like receptor 5 agonist for therapeutic applications

The Toll-like receptor 5 (TLR5) agonist entolimod, a derivative of Salmonella flagellin, has therapeutic potential for several indications including radioprotection and cancer immunotherapy. However, in Phase 1 human studies, entolimod induced a rapid neutralizing immune response, presumably due to...

Descripción completa

Detalles Bibliográficos
Autores principales: Mett, Vadim, Kurnasov, Oleg V., Bespalov, Ivan A., Molodtsov, Ivan, Brackett, Craig M., Burdelya, Lyudmila G., Purmal, Andrei A., Gleiberman, Anatoli S., Toshkov, Ilia A., Burkhart, Catherine A., Kogan, Yakov N., Andrianova, Ekaterina L., Gudkov, Andrei V., Osterman, Andrei L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041767/
https://www.ncbi.nlm.nih.gov/pubmed/33846531
http://dx.doi.org/10.1038/s42003-021-01978-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041767/
https://www.ncbi.nlm.nih.gov/pubmed/33846531
http://dx.doi.org/10.1038/s42003-021-01978-6

Ejemplares similares