An engineered ligand trap inhibits leukemia inhibitory factor as pancreatic cancer treatment strategy

Leukemia inhibitory factor (LIF), a cytokine secreted by stromal myofibroblasts and tumor cells, has recently been highlighted to promote tumor progression in pancreatic and other cancers through KRAS-driven cell signaling. We engineered a high affinity soluble human LIF receptor (LIFR) decoy that s...

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Detalles Bibliográficos
Autores principales: Hunter, Sean A., McIntosh, Brianna J., Shi, Yu, Sperberg, R. Andres Parra, Funatogawa, Chie, Labanieh, Louai, Soon, Erin, Wastyk, Hannah C., Mehta, Nishant, Carter, Catherine, Hunter, Tony, Cochran, Jennifer R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041770/
https://www.ncbi.nlm.nih.gov/pubmed/33846527
http://dx.doi.org/10.1038/s42003-021-01928-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041770/
https://www.ncbi.nlm.nih.gov/pubmed/33846527
http://dx.doi.org/10.1038/s42003-021-01928-2

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